This study analyzed the theoretical innovation strategies and their impact on success of knowledge-based entrepreneurial businesses intermediator's absorption capacity. In fact, this paper explores how knowledge-based firms use their innovation strategies, which have the greatest impact on their entrepreneurial success,based on their absorption capacity. The study population was companies based in Isfahan research centersandby simple random sampling of 196 companies were selected as research sample fordistribution of questionnaire. For data analysis and hypothesis of structural equation modeling,Smart PLS 2 partial least squares software was used. The results of this study shows that the impact of innovation strategy on absorption capacity is7.51%, and the impact on the absorption capacity of entrepreneurial success on knowledge-based firms is 7.46 %.